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Depletion of glutathione is commonly observed in neurodegenerative diseases like Alzheimer's and Parkinson's, contributing to neurodegeneration

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Is glutathione treatment completely safe for everyone

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The breakdown of oral glutathione in the gut is driven partly by the enzyme gamma-glutamyltransferase, which is why a conventional tablet raises blood glutathione only slightly (Buonocore et al., Oxidative Medicine and Cellular Longevity 2016, PMID 26649136)