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NICE has issued technology appraisals for semaglutide 2.4 mg (Wegovy) for weight management (TA875) and for tirzepatide (Mounjaro) for managing overweight and obesity , each with defined eligibility criteria

254,255 High-fat diet-fed mice treated with exendin-4 (a hormone found in the saliva of the Gila monster which is synthetically modified to produce exenatide for T2D treatment) had decreased mRNA levels of the pro-inflammatory cytokines tumour necrosis factor-alpha, monocyte chemoattractant protein 1 and signal transducer and activator of transcription 3

30 Furthermore, metabolic conditions such as iron deficiency can alter progenitor cell fate, favoring adipogenesis over osteogenesis, underscoring the sensitivity of these developmental processes to energetic signals

Medications like Ozempic and Wegovy work by mimicking natural GLP-1, while others target both GLP-1 and GIP receptors for a combined effect

The most frequently reported side effects of Ozempic are gastrointestinal in nature