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It is also thought that the chemical destruction is in part related to the dissolution of intercellular cement, which has been demonstrated to occur after 30 seconds of exposure
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However, glutathione operates through a completely different mechanism it's a recycler and detox cofactor rather than a direct free radical quencher
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This pathway can be inhibited by the cell-survival signaling pathways mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) and phosphoinositide 3-kinase (PI3K)/Akt (protein kinase B), which may protect the cells against the cytotoxic effects of VPA [210]
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