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First, we revealed that pre-infusion CAR T cell products from LTR have an altered immunometabolic signature acquiring features of memory T cells, which is associated with improved anti-tumor efficacy and persistence, including increased OXPHOS, markers of fatty acid oxidation, and PPP activities (Fig
Met metabolism is also essential for Treg survival after IL-2 deprivation, and solute carrier protein SLC43A2 plays a key role in Met uptake and maintenance of Treg growth activity
Source: Barrett, et al JAMA Surgery, September 17, 2025 Researchers correlated insurance claims data and electronic medical records in a system that owns both an insurance plan (Highmark) and a provider system (Allegheny Health), and compared total medical expense for over 30,000 individuals who had either metabolic and bariatric surgery (sleeve gastrectomy) or were treated with GLP-1 medications between 2018 and 2023
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Central Sleep Apnea: a Brief Review
