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Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)
Metabolism (2016) 65:1196207
Typical dose: 100300 mcg per dose, 13 daily on an empty stomach, raised gradually over a 12-week course
B., and Mootha, V
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