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The FDA has been clear about the risks

Despite promising results showed by pre-clinical studies, anti-VEGF monotherapy such as bevacizumab, sunitinib and aflibercept among others have only provided limited benefits in certain tumor types including advanced-stage renal cell carcinoma, hepatocellular carcinoma and colorectal carcinoma and have not shown efficacy in pancreatic adenocarcinoma, prostate cancer, breast cancer or melanoma [287]

When GLP-1 RA users fasted for approximately 13 h, their gastric content and volume were comparable to those of control patients not receiving GLP-1 RAs, indicating that extended fasting can normalize gastric physiology and reduce aspiration risk without the need to interrupt therapy

That said, competition is coming: Pfizers cotadutide (dual agonist) is in late-stage trials, and if approved, could eat into Lillys share