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Sig Transduct Target Ther 7 , 75 (2022)
Four pathways simultaneously
The main pathology associated with PDHc deficiencies is moderate to severe cerebral lactic acidosis that appears shortly after birth
The protocol for a 3mL vial: draw the desired BAC water volume into a sterile needle and syringe, inject slowly down the side of the vial (not directly onto the lyophilized cake), allow the cake to dissolve without agitation, then gently swirl (never vortex) to ensure complete dissolution
Two recent meta-analyses of randomized, placebo-controlled trials found no evidence that coenzyme Q 10 improved motor-related symptoms or delayed the progression of the disease when compared to placebo (68, 69)
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