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For a broader view of peptide pharmacology and why some molecules tolerate long-acting formats better than others, see our reference on peptide pharmacology and profiles such as semaglutide (weekly), which illustrates why extended exposure often comes with GI tradeoffs

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Despite that 510% WL is clinically beneficial, greater WL may be required for the individual to improve or achieve remission of some obesity-related complications [7, 8]