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Drug development for non-alcoholic steatohepatitis (NASH), also known as metabolic dysfunction-associated steatohepatitis (MASH), has been surprisingly challenging 1
For most nano-phytomedicines, an optimal hydrodynamic diameter of 50150 nm balances circulation time, endothelial uptake, and diffusion within the brain parenchyma, which is why SLNs, NLCs, PLGA NPs, and liposomes designed for CNS targeting typically fall within this range (118)
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