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Choice of the second agent to start alongside metformin should be based on the individual's priorities, preferences, and comorbidities [Grade D, Consensus]

Some employers expressed hope that life-style coaching would allow employees to have an off ramp and stop using GLP-1 drugs after some period of time

[20] Over the course of a 52 week double blind study to detect the efficacy and safety of dulaglutide monotherapy versus metformin in type 2 diabetes, the most common side effects seen were nausea, diarrhea, and vomiting [20]

Is there a role for IGF-1 in the development of second primary cancers

Seino, Y., Fukushima, M., & Yabe, D