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The native peptide GLP-1-G 2 ( 1 ) showed a decreased of blood glucose concentration after 30 min, proving its efficacy in vivo, although for a short time as a rapid raise to the initial concentration level is observed after 1 h

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The emergence of serious AEs, reduced drug tolerability, or injection fatigue could require a switch to another DMT from the same efficacy category (a horizontal switch)

The adverse event profile was statistically indistinguishable from placebo

doi:10.1002/oby.24067 Old VJ, Davies MJ, Papamargaritis D, Choudhary P, Watson EL