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The theoretical extension of this rationale to retatrutide is scientifically plausible but remains exploratory

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In contrast, Ipamorelin is highly selective

In a crossover study of healthy men who received a 2-hour infusion of synthetic human GLP-1, there was a 19% decrease in circulating angiotensin II levels, but no change in plasma levels of renin or aldosterone [67], and no alteration in renal hemodynamic function [67]