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Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

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The GST-M1- and T1-null allele frequencies of the global population have been estimated by the author of this review as 0.462 for GST-M1 and 0.244 for GST-T1, calculated as the average frequencies of different ethnic groups in the African, Asian and Caucasian races reported by Kasthurinaidu et al

Synergistic combinations with immunotherapy, radiotherapy or ferroptosis-inducing agents also hold strong potential