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For example, one large review article involving over 23,000 people with type 2 diabetes found that the maximum dose of Mounjaro reduced HbA1C by about 2%, while the maximum dose of Ozempic reduced it by 1.6%

Sun et al., 2022 Cryo-EM Structural Determinants Sun and colleagues reported cryo-electron microscopy structures of tirzepatide in complex with both the GIP receptor and the GLP-1 receptor in the Proceedings of the National Academy of Sciences in 2022 [3]

Your TSH, free T3, and free T4 levels should be stable and in range before starting semaglutide or tirzepatide

A 2026 retrospective study in The Lancet found that postmenopausal women receiving tirzepatide alongside hormone therapy were more than four times as likely to achieve 30% weight loss compared to those on tirzepatide alone: 18% versus 4%

If you're concerned about what the compounding changes mean for your weight loss treatment, our team can help you evaluate your options and create a plan that works for you