GSTZ1 Glutathione S-transferase Zeta 1 (also known as maleylacetoacetate isomerase ) is an enzyme that in humans is encoded by the GSTZ1 gene on chromosome 14
In addition to serving as a substrate for protein synthesis, Trp is metabolized through the Kyn pathway via IDO1/tryptophan 2,3-dioxygenase (TDO) to generate metabolites such as Kyn, which can influence inflammatory transcription and immune tolerance through signaling axes such as the AhR ( In the immune microenvironment, Trp can enter the Kyn pathway through IDO1 or TDO, generating Kyn and its downstream metabolites
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Bass C, Puinean AM, Zimmer CT, Denholm I, Field LM, Foster SP
For example, curcumin, an extract from the rhizome of the plant Curcuma longa mentioned above, inhibits ROS production and degrades KEAP1 to activate the NRF2/ARE pathway [455]