This underscores the need for integrated strategies combining pharmacotherapy with personalised dietary interventions and resistance exercise [24, 71], not only to preserve MM and support metabolic health but also to minimise the risk of nutritional deficiencies and sarcopenia [79,80,81]
Mechanistically, autocrine IGF-2 promotes self-activation by binding to the IGF-1 receptor (IGF-1R) on CAFs and activating PI3K/AKT signaling, followed by the secretion of various chemokines and cytokines (CCL5 and CXCL12) by CAFs to influence the infiltration of T cell
MMTT was performed in 3 days after 25 mg daily of alogliptin was changed to 0.75 mg weekly of dulaglutide, leaving the other antidiabetic drugs and insulin glargine unchanged
Insulin resistance, whether with type 2 diabetes or not, will lead to hyperglycemia, and de novo lipogenesis will be stimulated by high blood glucose
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