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They were originally developed for people with type 2 diabetes , but some are also licensed for weight management in the UK

Prolonged cAMP signaling and homologous desensitization Intuitively, reduced loss of surface GLP-1R with exendin-phe1 should permit greater access to extracellular ligand during continuous exposure, with fast recycling ensuring that the receptors are maintained in a sensitized state

This peptide is notable for its resistance to degradation by dipeptidyl peptidase-4 (DPP-4) and its relatively slow renal clearance

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