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Moreover, most natural products interact with multiple protein targets, exerting intricate biological effects in vivo (Wang Z

4.6.4 PI3K/Akt/mTOR pathway The PI3K/Akt/mTOR signaling pathway plays essential roles in various cellular processes, including growth, proliferation, and survival

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The 9-day assessment time point was determined based on previous studies using human scalp hair follicle ex vivo organ culture models, which reported that spontaneous catagen development frequently occurs between day 7 and day 10 under culture conditions