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In general cases, GH and IGF-1 induce promotion of tissue growth, wound healing, and cellular proliferation in young adults

Precipitating factors for the occurrence are: anemia, stress, xenobiotic toxicity, infection, neoplasia (e.g., histiocytic sarcoma), and pregnancy

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Pearson correlation analysis using GraphPad Prism 6 software was applied to evaluate the causal links between the tested parameters