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Sequence:39-amino-acid synthetic triagonist peptide (fatty-acid-modified) Origin: Engineered triple incretin analogue developed as a single-molecule agonist at GIP, GLP-1 and glucagon receptors

Retatrutide is a triple agonist (GIP, GLP-1, and glucagon receptors) while Ozempic activates only GLP-1 receptors, resulting in significantly greater weight loss, 24.2% versus 14.9% at standard doses

GLP-1 neurons in the nucleus tractus solitarius widely project to the central nervous system, including the hypothalamus (paraventricular nucleus, supraoptic nucleus, arcuate nucleus, and hypothalamic dorsomedial nucleus), brainstem (parabrachial nucleus, reticular formation, dorsal vagal nucleus), thalamus, and intermedio-lateral cell column

Some of these risk factors include high cholesterol, obesity, and diabetes

Insulin is a fat storing hormone