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Mendiola AS, Cardona AE
Historically, sermorelin acetate was marketed as Geref and used as a diagnostic and therapeutic agent for growth hormone deficiency, particularly in children, before being withdrawn from several markets for commercial reasons rather than safety concerns
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Of note, hemolysis is a fundamental feature of SCD and resulting excess hemin exposure 32 while hypoxia has been shown to induce the expression of fetal hemoglobin 33,34 , and promote the transition from expansion to differentiation during stress erythropoiesis 35
