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Insulin Direct administration of the hormone that is deficient in DM2 (insulin) is the most potent glucose-lowering option, particularly in insulinopenic patients, in whom the resulting expected mean HbA1c reduction is between 1 and 2%
The satiety effect tends to feel different from GLP-1-based appetite suppression
Some lean mass reduction is common in weight loss in general, but the amount varies a lot
The FDA originally approved Rybelsus in 2019 to improve glycemic control in adults with type 2 diabetes
2009 Apr;145(4):441-4
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