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End of combination therapy was defined as the day that treatment with metformin, the exposure drug, or the control drug ceased or when another glucose-lowering drug was initiated
Zayed MK, Iohara AR
When osteoclast activity exceeds osteoblast (bone-building) activity the net result is loss of bone density.' Research supports this, as one trial found that taking semaglutide (one form of GLP-1) was associated with lower bone density and an increased rate of bone breakdown
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However, anecdotal reports from women using semaglutide suggest mixed experiences: Some users have noticed reduced menstrual pain after significant weight loss and improved overall health
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