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These are FDA-approved medication options for chronic weight management when combined with a reduced-calorie diet and increased activity

Option 1: Compounded Retatrutide Retatrutide is not FDA-approved, but research-grade and compounded versions do exist through specific channels

ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER

In its Phase 3 trial results announced in May 2026, participants on the highest dose lost around 28 to 30 percent of their body weight over roughly two years, figures that put it ahead of most other weight loss medicines studied so far