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Pterostilbene (PTS) decreases the expression of HDAC and DNMT, leading to the demethylation of the NRF2 promoter and subsequent reactivation of NRF2

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51 Studies of dogs with osteoarthritis have shown that treatment with PEA plus quercetin, at a daily dose of 24 mg/kg body weight for four weeks, or a PEA derivative called palmitoyl-glucosamine plus curcumin for 12 months led to improvements in dog mobility and function and reductions in pain and lameness