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At 260lbs and soon to be a working dietitian, I again, got my shit together with good ole fashioned hard fought, highly focused diet and exercise

They compared around 215,000 people with diabetes prescribed weekly injections of GLP-1 agonists to just over 1.2 million people who continued to receive their usual non-GLP-1 medicines to reduce blood sugar

Body composition plays a role, with people who have more subcutaneous fat typically reporting easier injections

The strategic question is no longer whether these drugs work for obesity

Humphrey Ridley noticed a low permeability between the peripheral circulation and the brain [1, 2]