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Diarrhea (along with vomiting, another common side effect from these medications) can cause dehydration , leading to dry mouth

It also occurs in milder forms with symptoms such as tiredness, weakness, insomnia, depression, or loss of mental sharpness

This allows clear identification of which compound causes any effects

A 2021 review in Nature Reviews Molecular Cell Biology describes a gradual drop in tissue and cellular NAD+ across aging in rodents and humans, and links that fall to metabolic disease, cognitive decline, and sarcopenia [1]

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