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Delayed gastric emptying leaves food and liquid in the stomach longer, increasing stretch and chemical stimulus to visceral afferents that communicate with the brainstem nausea centers
What is the minimum effective dose of retatrutide
European Medicines Agency (2023)
Exploring the relationship between Efpeglenatide dose and cardiovascular outcomes in type 2 diabetes: insights from the AMPLITUDE-O trial
[1] When to Seek Medical Advice Seek immediate medical attention (call 999 or attend A&E) if you experience: Signs of severe allergic reaction (anaphylaxis) : difficulty breathing, swelling of face/lips/tongue/throat, severe rash or hives, rapid pulse, dizziness or fainting Contact NHS 111 or seek urgent GP advice if you develop: Severe, persistent abdominal pain (possibly radiating to the back), with or without vomiting, which may indicate pancreatitis [1] Severe upper right abdominal pain, fever, or yellowing of skin or eyes (jaundice), which may suggest gallbladder problems Severe or persistent gastrointestinal symptoms preventing adequate fluid or food intake Signs of dehydration (dark urine, dizziness, reduced urination, extreme thirst) Contact your GP if you notice: Persistent injection site reactions lasting more than one week Signs of infection at injection sites (increasing warmth, spreading redness, pus, fever) Recurrent hypoglycaemia if taking diabetes medications Unexplained visual changes or severe headaches A lump or swelling in the neck, persistent hoarseness, difficulty swallowing, or shortness of breath Symptoms of depression or suicidal thoughts (rare but reported) Routine follow-up with your prescribing clinician is essential for monitoring treatment response, managing side effects, and adjusting doses appropriately
