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Treatment of mice with oral melatonin (50 or 100 mg/kg) 4 or 8 hours before acetaminophen overdose suppressed the increase in serum ALT and AST activities in a dose- and a time-dependent manner, but had no effect on liver glutathione levels

Diabetes type 2 has a high prevalence in the obese (BMI 25kg/m 2 ) and overweight (BMI 30kg/m 2 ) population, and these patients tend to have poor diets and sedentary lifestyles

The bottom line: niacinamide provides the NAD+ precursor benefits without the uncomfortable flushing that niacin causes

The difference is size