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We also investigated the effect of NAC treatment on heme levels and found no significant differences (Fig 6C), thereby indicating that thiol elevation (rather than altered drug activation) is primarily responsible for the impact of NAC on artemisinin sensitivity

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Contact your healthcare provider if you experience severe or persistent heartburn unresponsive to treatment, difficulty swallowing, persistent vomiting, severe abdominal pain, or any signs of gastrointestinal bleeding such as vomiting blood or black, tarry stools