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Pharmacol Res 182:106292

Chronic Disease Prevention: Lowers the risk of chronic diseases such as heart disease, cancer, and neurodegenerative disorders

Long-Term: Reduction of fine lines, firmer skin, and enhanced elasticity

When NRX is oxidized by NADPH oxidase 1 (NOX1)-derived H2O2 or lipid peroxide (ROOH), DVL is released and inhibits glycogen synthesis kinase 3 (GSK3) in the -catenin degradation complex, thereby stabilizing the -catenin in the cytoplasm and partially entering the nucleus to activate the target gene GPX2 by correlation with the TCF/LEF transcription factor family (Figure 2)

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