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Patients in their 20s with specific genetic profiles sometimes require slower dose escalation than patients in their 50s with different genetic backgrounds, highlighting why age alone is insufficient for clinical planning

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this hypothesis is also given credence by the common finding of GSTP overexpression in tumor cell lines that are not drug resistant

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PT-141 is a manmade substance that mimics natural a-MSH, a melanocortin (1)

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