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Semaglutide is injected subcutaneously, into tissue far above major blood vessels
111 A remaining question is whether potential controlling factors including allosteric control of glycogen synthase (GS) and phosphorylases via glucose-6-phosphate (G6P), 112 in addition to the insulin-independent transport of glucose across the hepatocellular plasma membrane by GLUT2 (as a glucose-sensitive protein in liver cells), can impact hepatic glycogen metabolism
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These results may inform research into psychiatric safety and potential repurposing opportunities for GLP-1RAs, especially in people with mental health disorders, but randomized clinical trials are needed to determine whether the genetic associations translate into treatment benefits
Then give people access to GLP-1s
