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By relying on 1:1 interactions, there is a limit on how many patients can see a specialist, such as a nutritionist, on a frequent basis
Supports sleep regulation and circadian rhythms
And in short that came out a few years after that STEP 1 trial what we did for the very first time is take individuals with obesity and pre-existing cardiovascular disease, like a prior stroke, prior heart attack, or peripheral arterial disease, called PAD, and they're on maximal therapy for their cardiovascular disease or stroke, and then randomized them on top of that to either semaglutide or placebo
Some patients remain on lower maintenance doses because of gastrointestinal side effects or delayed titration schedules
A total of 75 out of 88 target genes were evaluable
