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The elevated DNA damage and altered DNA methylation are risks for cancer and play essential roles in neurological, and developmental abnormalities and cognitive defects (22, 66)

Because recurrence is common, surgical removal of the gallbladder, known as cholecystectomy, is widely recommended following an acute episode of gallstone cholecystitis (Jones, Ghassemzadeh 2018

Some providers are more flexible with eligibility criteria than others