Since a large population of motor neurons and axons remain intact at symptom onset, the role of the immune system might be to protect these remaining neurons from degeneration
During stress from calving/lambing or transportation
Jos A, Trujillo-Hernandez L, Bariat TA, Enders LC, Strader J-P, Reichheld, Christophe Belin (2020) A glutathione-dependent control of the indole butyric acid pathway supports Arabidopsis root system adaptation to phosphate deprivation
While oral vitamin B12 supplements must go through your digestive system before entering the bloodstream, vitamin B12 injections are delivered right to the bloodstream so you get the full benefits of the dosage
Since the net charge of CAND is -0.2, resulting in an overall neutral charge, it is difficult for CAND to be effectively transported to the cell nucleus on its own