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Retatrutide (LY-3437943) is an investigational triple agonist activating: GLP-1 receptors GIP receptors Glucagon receptors This triple-pathway mechanism has produced some of the largest average weight-loss outcomes reported in obesity trials , positioning retatrutide as one of the most potent investigational metabolic agents to date
Participants had about 15% average weight loss with the highest dose (2.4 mg) within a similar timeframe
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Preclinical studies suggest potential anti-inflammatory effects, but no randomised controlled trials have evaluated GLP-1 agonists for rheumatoid arthritis treatment
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