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While existing research has identified hyperuricemia involvement in numerous biological processes and signaling pathways, the precise mechanisms connecting elevated UA levels to disease etiology remain to be fully elucidated

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In normal conditions, the loading conditions activate the Piezo1 channel in bone marrow mesenchymal stem cells, which leads to the repression of the Ccl2-Lcn2 inflammatory cascade and a tendency toward osteogenesis instead of adipogenesis (290)

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