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11 Vildagliptin is particularly useful in older patients, either combined with metformin or alone if metformin is contraindicated or not tolerated
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This occurs because the pituitary gland and adipose tissue are stimulated to produce androgens and luteinizing hormone, respectively, in response to increasing levels of androgens, which in turn heighten insulin resistance (IR) and hyperinsulinemia (Hg)
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