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Research also indicates that tri-agonist signaling can influence adipose tissue distribution and body composition parameters measured in clinical and experimental settings
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8 Challenges in clinical application Considering the enumerated benefits of GLP-1RA compared to other glucose-lowering drugs including the reduction in HbA1c and weight reduction benefits alongside decreased risk for hypoglycaemia (122) it is not cost effective if used in combination with another incretin (107)
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