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The 11.2% discontinuation rate at the highest dose means nearly 89% of participants tolerated treatment successfully through 48 weeks

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Complete prevention of weight regain is uncommon, but maintaining even 5-10% weight loss below starting weight provides significant health benefits, including improved cardiovascular risk factors and glycemic control

Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice