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These findings indicate that GLP-1R activation specifically inhibits GSDMD-mediated microglial pyroptosis, a finding consistently replicated in subsequent in vitro experiments (Song et al., 2022)
Cardiovascular Diabetology
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furthermore, could down-regulate release of proinflammatory Th1 cytokines (i.e., TNF- and IFN-) and stimulate macrophages to generate anti-inflammatory cytokines to minimize the risk of ARDS in COVID-19 691
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