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Your body burns stored fat for energy more efficiently while storing less new fat from your diet

86 MoriguchiS.TakamiyaA.NodaY.HoritaN.WadaM.TsugawaS.et al (2019)

While the test is designed to optimize medication selection before pregnancy, understanding your unique genetic predispositions to insulin sensitivity and appetite regulation can inform lifestyle strategies you use during the pre-conception washout period and inform your healthcare team's recommendations

And when the skin gets darker, if it's really dark, what we would call it, Addison's disease, right

For example, patients taking enzyme-inducing antiepileptic drugs (carbamazepine, phenytoin, and phenobarbital) will clear valproate more rapidly