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Active folate is also essential for healthy DNA synthesis during conception and pregnancy
and trials in osteoarthritis where pain/inflammation measures improved, even before major weight loss
This neuroendocrine normalization may underlie many of the compound's systemic anti-aging effects
Based on in vitro findings, Hst1 decreased staining for senescence-associated -galactosidase activity and expression of mediators of senescence signaling, including p53, p21, and p16
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