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established a two-stage chemical cocktail to directly reprogram MEFs to iHeps (Bai et al., 2023), modified from the cocktails (C6FAE and C6F5UE) presented in Yangs work (Yang et al., 2020)

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Figure 5 Downstream cellular mediators of Dihexa protection Activation of the receptor tyrosine kinase c-Met leads to the recruitment of many signaling mediators and ultimately the activation of downstream signals, most notably Akt-TOR and Ras-ERK (Organ and Tsao, 2011)

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