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Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy)

( A ) Representative Western blot of 50-kDa sAC isoform expression in WT mouse lysates of whole heart (Hrt), LV, right ventricle (RV), atria (Atr), septum (Sep), and brain (Br, negative control)

While not FDA-approved for PCOS, it works by blocking androgen receptors and reducing androgen production

Studies indicate that patients with lower BMI respond better to biological therapies, potentially because reduced adipose tissue decreases the inflammatory burden and may improve drug pharmacokinetics

429 Precision medicine guided by genetic insights holds promise for tailoring hyperuricemia management to individualized needs