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The strongest peer-reviewed human data remain the Phase 2 obesity trial [1] and the Phase 2 MASH trial, [2] supported by Phase 2 diabetes [4] and Phase 1 cirrhosis [5] data
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42 Furthermore, considerations for appropriate footwear and playing surfaces can also play a role in mitigating biomechanical risks
Because it escapes binding to these inhibitory proteins, IGF-1 LR3 remains free in experimental environments to interact continuously with the IGF-1 receptor, resulting in an extended biological half-life and vastly increased potency compared to standard IGF-1
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