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Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone (SURPASS) studies have shown that tirzepatide reduced HbA1c and fasting glucose levels more than the titrated insulin degludec, insulin glargine or 1 mg once a week semaglutide independently of the baseline levels of HbA1c
Below is a detailed breakdown of the contraindications and situations where semaglutide use is not recommended
Belanger, B
Reduces The Risk of Macular (Eye) Degeneration When compared to people with adequate Vitamin B12 levels, those with a deficit have over double the risk of developing AMD, which is a disease of the macula
As RMR did not increase with semaglutide, it may be inferred that weight loss was likely as a result of reduced energy intake (181)
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