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While semaglutides risk was similar to some non-GLP-1 drugs like sitagliptin (Januvia) and glipizide (Glucatrol), the comparison with empagliflozin (Jardiance) revealed a higher risk (HR: 2.27) when more specific case definitions were used

While tirzepatide functions as a dual GIP/GLP-1 receptor agonist, semaglutide uses GLP-1 receptors

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Decreases food-related reward sensations, making it easier to resist cravings 2

In studies in dogs with liver disease, supplementation with 12.7515 mg silybin (a flavonoid from milk thistle) per 10 kg body weight per day for 2860 days reduced biomarkers of liver damage and improved liver function tests