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Peer review Peer review information Nature Medicine thanks Henrick Imberg, Sten Madsbad, Miguel A

Blood was collected from the tail vein and blood glucose levels was measured before the injection and 4, 8, 10, 24 and 48 h after dosing in fed conditions

2014 A Qualitative Study to Understand the Supportive Care Needs of Adolescents with X-Linked Hypophosphatemia during the Transition to Adulthood Angela Rylands 1 , Vrinda Saraff 2 , Pedro Arango Sancho 3 , Justine Bacchetta 4 , Annemieke Boot 5 , Christine Burren 6 , Amish Chinoy 7 , Poonam Dharmaraj 8 , Adele Barlassina 9 , Agns Linglart 10 , Maria Amelia Gmez Llorente 11 , Juan David Gonzlez Rodrguez 12 , Iva Gueorguieva 13 , Wesley Hayes 14 , Hctor Ros Duro 15 , Emily Hardie 16 , Dirk Schnabel 17 , Santhani Selveindran 18 1 Kyowa Kirin Ltd, Marlow, UK, 2 Birmingham Womens and Childrens Hospital, Birmingham, UK, 3 Sant Joan de Du Barcelona Hospital, Barcelona, Spain, 4 Hospices Civils de Lyon, INSERM1033 Research Unit, Lyon, France, 5 University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 6 University Hospitals Bristol and Weston NHS Foundation Trust, Briston, UK, 7 Royal Manchester Childrens Hospital, Manchester, UK, 8 Alder Hey Childrens Hospital, Liverpool, UK, 9 Open Health Ltd, Rotterdam, Netherlands, 10 AP-HP, Paris Saclay University, Paris, France, 11 Hospital Virgen de Las Nieves, Granada, Spain, 12 Department of Pediatric Nephrology, Santa Lucia General University Hospital, Cartagena, Spain, 13 Centre Hospitalier Universitaire de Lille, Lille, France, 14 Great Ormond Street Hospital, London, UK, 15 Pediatric Nephrology, Vall dHebron Universitary Hospital, Barcelona, Spain, 16 Kyowa Kirin International, Marlow, UK, 17 Center for Chronic Sick Children, Pediatric Endocrinology, Charit University Medicine Berlin, Berlin, Germany, 18 Open Health Ltd, London, UK Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :2014 Aims X-linked hypophosphatemia (XLH) is a rare, genetic disorder caused by pathogenic variants in the phosphate-regulating endopeptidase homologue X-linked (PHEX) gene

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It is found in large quantities in many cells in the body (1-10 millimoles/L)